Interference Suppression in Massive MIMO VLC Systems

The focus of this dissertation is on the development and evaluation of methods and principles to mitigate interference in multiuser visible light communication (VLC) systems using several transmitters. All components of such a massive multiple-input multiple-output (MIMO) system are considered and transformed into a communication system model, while also paying particular attention to the hardware requirements of different modulation schemes. By analyzing all steps in the communication process, the inter-channel interference between users is identified as the most critical aspect. Several methods of suppressing this kind of interference, i.e. to split the MIMO channel into parallel single channels, are discussed, and a novel active LCD-based interference suppression principle at the receiver side is introduced as main aspect of this work. This technique enables a dynamic adaption of the physical channel: compared to solely software-based or static approaches, the LCD interference suppression filter achieves adaptive channel separation without altering the characteristics of the transmitter lights. This is especially advantageous in dual-use scenarios with illumination requirements. Additionally, external interferers, like natural light or transmitter light sources of neighboring cells in a multicell setting, can also be suppressed without requiring any control over them. Each user's LCD filter is placed in front of the corresponding photodetector and configured in such a way that only light from desired transmitters can reach the detector by setting only the appropriate pixels to transparent, while light from unwanted transmitters remains blocked. The effectiveness of this method is tested and benchmarked against zero-forcing (ZF) precoding in different scenarios and applications by numerical simulations and also verified experimentally in a large MIMO VLC testbed created specifically for this purpose

Liquid Crystal Display Based Angle-of-Arrival Estimation of a Single Light Source

In this paper, a novel concept for visible light positioning is introduced, which employs a liquid crystal display as a dynamic optical filter in front of a photodetector. By electronically switching dedicated pixel areas in transparent or blocking mode, respectively, the angle of arrival is estimated. The measurement principle is supported by a mathematical model. Finally, an experimental setup is presented and measurement results are compared to the theoretical findings

Impact of Liquid Crystal Based Interference Mitigation and Precoding on the Multiuser Performance of VLC Massive MIMO Arrays

In visible light communication systems, the ability to suppress interference caused by other light sources is a major benefit towards performance improvements. Especially for large transmitter arrays or even multi-cell arrangements, the interference problem needs to be handled. In previous work, we have presented a liquid crystal display (LCD) used as an adaptive interference-suppression filter mounted in front of each photodetector. The display elements are switched on and off in such a way that light emitted by unwanted light sources ideally is blocked, but light emitted by desired light sources reaches the detector. The pattern generated by the LC display has strong impact on the system performance. In this paper, we propose combined precoding in conjunction with LCD-based interference suppression in order to increase the signal-to-interference-plus-noise ratio and to ensure user fairness in massive MIMO scenarios. The suggested precoding strategy uses a new heuristic optimization approach based on the Santa Claus problem on unrelated machines known from computer sciences, and employs only binary entries in the weighting matrix. Corresponding results are compared with a genetic evolutionary optimization strategy and with conventional zero-forcing precoding. Regarding performance evaluation, we perform numerical ray-tracing simulations and present a room-scale VLC testbed for experimental verification

Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, 'private' autoantibody reactivities shared by only a few patients but collectively targeting >1000 autoantigens have been attributed to false positives (Landegren, 2019). While acknowledging this risk, our study-design included follow-up validation, permitting us to adopt statistical approaches to also limit false negatives. Importantly, many such private specificities have now been validated by multiple, independent means including the autoantibodies ' molecular cloning and expression. Second, a significant correlation of antibody-mediated IFN a neutralization with an absence of disease in patients highly disposed to Type I diabetes has been challenged because of a claimed failure to replicate our findings (Landegren, 2019). However, flaws in design and implementation invalidate this challenge. Thus, our results present robust, insightful, independently validated depictions of APECED/APS1, that have spawned productive follow-up studies.Non peer reviewe

Timing of Optical Maturation of Recently Exposed Material on Ceres

On Ceres, multispectral imaging data from the Dawn spacecraft show a distinct bluish characteristic for recently exposed material from the subsurface in, for example, crater ejecta. Ejecta blankets of presumably old craters show a more reddish spectrum. We selected areas in which fresh material from the Cerean subsurface was exposed at a specific time in the past, and no later geologic process is expected to have changed its surface composition or its cratering record. For each area, we determined two color ratios and the crater retention age. The measured color ratios show an exponential diminishment of the bluish characteristic over time. Although the cause of the color change remains uncertain, the time-dependent change in spectral properties is evident, which could help identify the process

Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Protiens

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for major autoimmune diseases. AIRE deficiency severely reduces thymic expression of gene-products ordinarily restricted to discrete peripheral tissues, and developing T cells reactive to those gene-products are not inactivated during their development. However, the extent of the autoantibody repertoire in APECED and its relation to thymic expression of self-antigens are unclear. We here undertook a broad protein array approach to assess autoantibody repertoire in APECED patients. Our results show that in addition to shared autoantigen reactivities, APECED patients display high inter-individual variation in their autoantigen profiles, which collectively are enriched in evolutionarily conserved, cytosolic and nuclear phosphoproteins. The APECED autoantigens have two major origins; proteins expressed in thymic medullary epithelial cells and proteins expressed in lymphoid cells. These findings support the hypothesis that specific protein properties strongly contribute to the etiology of B cell autoimmunity.Peer reviewe

MFA12 (MFA 2012)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum May 4-Aug. 6, 2012. Contents include Introduction / Buzz Spector -- Think, make, show and tell / Patricia Olynyk -- Ifeoma Ugonnwa Anyaeji -- J.E. Baker / Elissa Yukiko Weichbrodt -- Natalie Baldeon / Emily Hanson -- As in a turning gear : E. Thurston Belmer / Rickey Laurentiis -- Lauren Cardenas / Nicholas Tamarkin -- Megan Sue Collins / Catherine Chiodo -- Adrian Cox -- Maya Durham / Dolly Laninga -- Erin Falker / Melissa Olson -- St. Louis dreamscape : Jieun Kim / Caitlin Tyler -- Howard Krohn -- Scape : Robert Long / Robert Whitehead -- Marie Bannerot McInerney / Elissa Yukiko Weichbrodt -- Ghost : Nikki McMahan / Rickey Laurentiis -- Michael T. Meier -- Katie Millitzer -- Reid G. Norris / Ross Rader -- Kathleen Perniciaro / Melissa Olson -- Emily Squires / Nicholas Tamarkin -- Jamie Presson Wells -- Whitney Lorene Wood / Reid G. Norris -- Andrew Woodard -- Kelly K. Wright -- Contributors -- About the Sam Fox School.https://openscholarship.wustl.edu/books/1003/thumbnail.jp

Characteristics of Polygonal Craters on (1) Ceres

The Dawn spacecraft arrived at Ceres in March 2015. There, the on-board Framing Camera (FC) collects image data with a resolution of up to 35 m/pixel, which reveal a large variety of impact crater morphologies including polygonal craters. Polygonal craters show straight rim sections aligned to form an angular shape. They are com- monly associated with fractures in the target material, which may be preserved as linear structures on Ceres [3, 4]. On Ceres, we find polygonal craters with a size ranging between 5 km and 280 km in diameter. However, the ma- jority of polygonal craters have diameters ranging between 10 km and 50 km diameter. A preferential hexagonal shape is observed and some polygonal craters exhibit central peaks or relaxed crater floors. On average there are eight to ten polygonal craters per 100,000 km 2 , however the northern latitudes have a slightly higher and the southern latitudes a slightly lower polygonal crater density. This may hint at an older and younger age of the northern (> 60°N) and southern regions (> 60°S) compared to the mid latitudes, respectively. Alter- natively, the relaxation of craters may be advanced in the mid latitudes which are generally warmer than the poles and thus support the relaxation of depressions. Also, the southern region harbors relatively large craters which may have altered or destroyed preexisting structures in the crust which are necessary for the formation of polygonal craters. Most polygonal craters have six or seven straight rim sections; however, there is a tendency for fewer edges with decreasing crater size. Although this observation may be biased due to the map resolution, it is also possible that the impactor creating a relatively small polygonal crater embeds less energy and thus forms the straight rim sections during the excavation stage. This may result in fewer straight rim sections compared to more energetic impactors which form their polygonal shape during the modification stage. Straight rim sections and edges of polygonal craters often align with linear features associated with Ceres’ tec- tonics. Small and medium-sized polygonal crater rims tend to align with the general direction of linear features, whereas very large polygonal crater edges tend to be intersected by the linear features. This may hint at the differ- ent formation processes of polygonal craters depending on the embedded energy. In contrast, polygonal craters are also present in areas with no obvious tectonic features. These polygonal craters may be produced by subresolution or subsurface fractures. [3] Buczkowski, D. et al., GSA 2015, 1-4 November 2015, Baltimore, MD, USA, #282-8, 2015 [4] von der Gathen, I. et al., GSA 2015, 1-4 November 2015, Baltimore, MD, USA, #282-9, 201